Wellness Doesn’t Just Miraculously Appear.

It is generally accepted that health doesn’t just miraculously appear. Rather, it is the end result of a process that begins at the cellular level in the body and cascades through tissues and organs to ultimately be identified at the clinical level. To be clinically healthy, it is essential that the process start with healthy cells and molecules, the basic building blocks of tissues and organs. Health, therefore, is a cellular event that ultimately expresses itself clinically. That is why nutrition is so important. Nutrition not only supplies energy, it also provides the ingredients the body uses to create cells and molecules. For optimal health, there must be optimal function at the cellular level. For optimal function, there must be optimal structure. One follows the other.
Most proteins in the body are glycosylated, meaning they have sugar molecules, known as carbohydrates, attached to them. They are not simply proteins, they are glycoproteins. The carbohydrates are an integral part of the overall three-dimensional structure of glycoproteins and, therefore, have a significant effect on their function. It would, therefore, be important to know if adding a glyconutritional supplement to the diet has any impact on the glycosylation profile of glycoproteins.

What’s the Effect of Adding Advanced Ambrotose Powder to Your Diet?

A recent human clinical study, published in a major peer-reviewed international nutrition journal, helps to answer that question. The results document conclusively that the ingestion of Advanced Ambrotose powder can affect the body at a basic level by significantly altering the glycosylation of glycoproteins. Researchers at St. George’s Hospital Medical School, University of London, studied the N-linked carbohydrate component of serum glycoproteins in the blood of a group of healthy adults.(1)† Over a number of weeks they measured the glycosylation of these serum glycoproteins in order to establish a baseline. The study participants were then given increasing amounts of Advanced Ambrotose powder at regular bi-weekly intervals with protein glycosylation being measured at each step. What they found was very interesting. The ingestion of Advanced Ambrotose powder altered the glycosylation profiles in the participants’ serum. Moreover, the more of the product the participants ingested, the more the glycosylation profiles changed. Clearly, the glycosylation changes were directly attributable to the ingestion of the Advanced Ambrotose powder, and it was happening in a dose-dependent manner.
This is a very important clinical study. It is the opinion of the investigators that this is the first time that glycosylation changes have been documented in healthy subjects as a consequence of nutritional intervention. The nutritional intervention in this case was the addition of the nutritional supplement Advanced Ambrotose powder to the diet. The full clinical implications of these glycosylation changes have yet to be determined. What can be said conclusively is that the ingestion of Advanced Ambrotose powder affects the body at a basic level. This is a scientifically valid, peer-reviewed, objective study that has nothing to do with symptoms or how people feel. Once and for all, this negates the opinions of so-called experts and miscellaneous detractors who argue, for their own varied reasons, that Mannatech’s glyconutritional supplements cannot have an effect on the body. They do! In fact, previous human clinical studies have also documented cognitive, well-being and gastrointestinal benefits (2),(3),(4).* Mannatech’s glyconutritional supplements work, and you can take that to the bank!
Check out more details of this and other studies on the website MannatechScience.org.
Dr. Stephen Boyd is a paid consultant for Mannatech, Incorporated.
†This research was funded by a research grant from Mannatech, Incorportated.
1. Alavi A, Fraser O, Tarelli E, Axford J. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation profile of serum in healthy subjects. Eur J Clin Nutr 2008;65:648-56.
2. Best T, Kemps E, Bryan J. Perceived changes in well-being following polysaccharide intake in middle-aged adults. Applied Res Qual Life 2011, DOI: 10.1007/s/11482-001-9158-2.
3. Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Dev Neuropsych 2010;35:66-80.
4. Stancil AN, Hicks LH. Glyconutrients and perception, cognition, and memory. Perceptual Mot Skills 2009;10:259-70.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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For more information on Ambrotose http://tinyurl.com/3pfzjqt